ARID4A

ARID4A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LCC, 2MAM, 2YRV
Identifiers
Aliases	ARID4A, RBBP-1, RBBP1, RBP-1, RBP1, AT-rich interaction domain 4A
External IDs	MGI: 2444354 HomoloGene: 11303 GeneCards: ARID4A
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • DNA binding • histone deacetylase activity Cellular component • transcriptional repressor complex • nucleus • nucleoplasm • cytosol • plasma membrane Biological process • histone H3-K9 trimethylation • establishment of Sertoli cell barrier • regulation of transcription, DNA-templated • regulation of gene expression by genetic imprinting • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • erythrocyte development • regulation of transcription from RNA polymerase II promoter • spermatogenesis • histone H4-K20 trimethylation • histone H3-K4 trimethylation • transcription, DNA-templated • negative regulation of transcription, DNA-templated • histone deacetylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5926	238247
Ensembl	ENSG00000032219	ENSMUSG00000048118
UniProt	P29374	n/a
RefSeq (mRNA)	NM_002892 NM_023000 NM_023001	NM_001081195
RefSeq (protein)	NP_002883 NP_075376 NP_075377	n/a
Location (UCSC)	Chr 14: 58.3 – 58.37 Mb	Chr 12: 71.02 – 71.1 Mb
PubMed search

2LCC, 2MAM, 2YRV

5926

238247

ENSG00000032219

ENSMUSG00000048118

P29374

n/a

NM_002892
NM_023000
NM_023001

NM_001081195

NP_002883
NP_075376
NP_075377

n/a

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.

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