ALOX12B

ALOX12B
Identifiers
Aliases	ALOX12B, 12R-LOX, ARCI2, arachidonate 12-lipoxygenase, 12R type
External IDs	MGI: 1274782 HomoloGene: 884 GeneCards: ALOX12B
Gene ontology Molecular function • iron ion binding • arachidonate 12-lipoxygenase activity • dioxygenase activity • metal ion binding • protein binding • catalytic activity • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • linoleate 9S-lipoxygenase activity Cellular component • cytoplasm • cytosol Biological process • linoleic acid metabolic process • establishment of skin barrier • lipid metabolic process • ceramide biosynthetic process • fatty acid metabolic process • lipoxygenase pathway • hepoxilin biosynthetic process • positive regulation of gene expression • protein lipidation • positive regulation of mucus secretion • oxidation-reduction process • sphingolipid metabolic process • positive regulation of MAPK cascade • arachidonic acid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	242	11686
Ensembl	ENSG00000179477	ENSMUSG00000032807
UniProt	O75342	O70582
RefSeq (mRNA)	NM_001139	NM_009659
RefSeq (protein)	NP_001130	NP_033789.1 NP_033789
Location (UCSC)	Chr 17: 8.07 – 8.09 Mb	Chr 11: 69.16 – 69.17 Mb
PubMed search

242

11686

ENSG00000179477

ENSMUSG00000032807

O75342

O70582

NM_001139

NM_009659

NP_001130

NP_033789.1
NP_033789

Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, 12R-LOX, and arachiconate lipoygenase 3, is a lipoxygenase-type enzyme composed of 701 amino acids and encoded by the ALOX12B gene. The gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOXE3 and ALOX15B. Among the human lipoxygenases, ALOX12B is most closely (54% identity) related in amino acid sequence to ALOXE3

ALOX12B oxygenates arachidonic acid by adding molecular oxygen (O₂) in the form of a hydroperoxyl (HO₂) residue to its 12th carbon thereby forming 12(R)-hydroperoxy-5Z,8Z,10E,14Z-icosatetraenoic acid (also termed 12(R)-HpETE or 12R-HpETE). When formed in cells, 12R-HpETE may be quickly reduced to its hydroxyl analog (OH), 12(R)-hydroxy-5'Z,8Z,10E,14Z-eicosatetraenoic acid (also termed 12(R)-HETE or 12R-HETE), by ubiquitous peroxidase-type enzymes. These sequential metabolic reactions are:

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Wikipedia