AIM2

AIM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RN2, 3RN5, 3VD8, 4O7Q
Identifiers
Aliases	AIM2, PYHIN4, absent in melanoma 2
External IDs	MGI: 2686159 HomoloGene: 83226 GeneCards: AIM2
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1-q23.2 Start 159,062,484 bp End 159,147,096 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H3 Start 173,350,879 bp End 173,466,040 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein binding • identical protein binding • double-stranded DNA binding Cellular component • cytoplasm • AIM2 inflammasome complex • nucleus • nucleoplasm • mitochondrion • cytosol Biological process • positive regulation of cysteine-type endopeptidase activity • pyroptosis • cellular response to interferon-beta • immune system process • tumor necrosis factor-mediated signaling pathway • cellular response to drug • interleukin-1 beta secretion • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-1 beta secretion • immune response • positive regulation of interleukin-1 beta production • positive regulation of protein oligomerization • activation of innate immune response • inflammatory response • negative regulation of NF-kappaB transcription factor activity • positive regulation of defense response to virus by host • apoptotic process • innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9447	383619
Ensembl	ENSG00000163568	ENSMUSG00000037860
UniProt	O14862	Q91VJ1
RefSeq (mRNA)	NM_004833 NM_001348247	NM_001013779
RefSeq (protein)	NP_004824 NP_001335176	NP_001013801
Location (UCSC)	Chr 1: 159.06 – 159.15 Mb	Chr 1: 173.35 – 173.47 Mb
PubMed search

3RN2, 3RN5, 3VD8, 4O7Q

9447

383619

ENSG00000163568

ENSMUSG00000037860

O14862

Q91VJ1

NM_004833
NM_001348247

NM_001013779

NP_004824
NP_001335176

NP_001013801

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene. Recent research has shown that AIM2 is part of the inflammasome and contributes to the defence against bacterial and viral DNA.

AIM2 is a 343 amino acid protein with a N-terminal DAPIN (or pyrin) domain (amino acids 1-87) and a C-terminal HIN-200 domain (amino acids 138-337), which is known to have two oligonucleotide-binding folds.

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Wikipedia