AICDA

AICDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JJ4
Identifiers
Aliases	AICDA, AID, ARP2, CDA2, HEL-S-284, HIGM2, activation-induced cytidine deaminase, activation induced cytidine deaminase
External IDs	MGI: 1342279 HomoloGene: 7623 GeneCards: AICDA
Gene ontology Molecular function • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines • zinc ion binding • protein binding • catalytic activity • hydrolase activity • ubiquitin protein ligase binding • metal ion binding • cytidine deaminase activity Cellular component • exosome (RNase complex) • nucleus • cytoplasm Biological process • somatic hypermutation of immunoglobulin genes • DNA demethylation • mRNA processing • B cell differentiation • somatic diversification of immunoglobulins • negative regulation of methylation-dependent chromatin silencing • cytidine deamination • cellular response to lipopolysaccharide • isotype switching • defense response to bacterium Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57379	11628
Ensembl	ENSG00000111732	ENSMUSG00000040627
UniProt	Q9GZX7	Q9WVE0
RefSeq (mRNA)	NM_020661 NM_001330343	NM_009645
RefSeq (protein)	NP_001317272 NP_065712	NP_033775
Location (UCSC)	Chr 12: 8.6 – 8.61 Mb	Chr 6: 122.55 – 122.56 Mb
PubMed search

5JJ4

57379

11628

ENSG00000111732

ENSMUSG00000040627

Q9GZX7

Q9WVE0

NM_020661
NM_001330343

NM_009645

NP_001317272
NP_065712

NP_033775

Activation-induced cytidine deaminase, also known as AICDA and AID, is a 24 kDa enzyme which in humans is encoded by the AICDA gene. It creates mutations in DNA by deamination of cytosine base, which turns it into uracil (which is recognized as a thymine). In other words, it changes a C:G base pair into a U:G mismatch. The cell's DNA replication machinery recognizes the U as a T, and hence C:G is converted to a T:A base pair. During germinal center development of B lymphocytes, AID also generates other types of mutations, such as C:G to A:T. The mechanism by which these other mutations are created is not well-understood.

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