AFP screening

AFP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MRK
Identifiers
Aliases	AFP, AFPD, FETA, HPalpha fetoprotein
External IDs	OMIM: 104150 MGI: 87951 HomoloGene: 36278 GeneCards: AFP
Gene ontology Molecular function • metal ion binding • protein binding Cellular component • extracellular region • extracellular space • cytoplasm • cytosol Biological process • ovulation from ovarian follicle • SMAD protein signal transduction • sexual reproduction • transport • progesterone metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	174	11576
Ensembl	ENSG00000081051	ENSMUSG00000054932
UniProt	P02771	P02772
RefSeq (mRNA)	NM_001134	NM_007423
RefSeq (protein)	NP_001125	NP_031449.3
Location (UCSC)	Chr 4: 73.43 – 73.46 Mb	Chr 5: 90.49 – 90.51 Mb
PubMed search

3MRK

174

11576

ENSG00000081051

ENSMUSG00000054932

P02771

P02772

NM_001134

NM_007423

NP_001125

NP_031449.3

Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the AFP gene. The AFP gene is located on the q arm of chromosome 4 (4q25).

AFP is a major plasma protein produced by the yolk sac and the liver during fetal development. It is thought to be the fetal form of serum albumin. AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms.

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