ADAM9

ADAM9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1V
Identifiers
Aliases	ADAM9, CORD9, MCMP, MDC9, Mltng, ADAM metallopeptidase domain 9
External IDs	MGI: 105376 HomoloGene: 20824 GeneCards: ADAM9
Gene ontology Molecular function • collagen binding • SH3 domain binding • metal ion binding • integrin binding • peptidase activity • protein binding • metalloendopeptidase activity • laminin binding • hydrolase activity • metallopeptidase activity • protein kinase C binding Cellular component • integral component of membrane • membrane • focal adhesion • intrinsic component of external side of plasma membrane • plasma membrane • extracellular region • extracellular exosome • cell surface • basolateral plasma membrane • extracellular space Biological process • activation of MAPKK activity • positive regulation of membrane protein ectodomain proteolysis • response to glucocorticoid • positive regulation of macrophage fusion • cell-cell adhesion mediated by integrin • keratinocyte differentiation • proteolysis • monocyte activation • response to calcium ion • response to tumor necrosis factor • positive regulation of keratinocyte migration • cell adhesion • response to manganese ion • membrane protein ectodomain proteolysis • PMA-inducible membrane protein ectodomain proteolysis • positive regulation of protein secretion • integrin-mediated signaling pathway • positive regulation of cell adhesion mediated by integrin • cell-matrix adhesion • cellular response to lipopolysaccharide • transforming growth factor beta receptor signaling pathway • response to hydrogen peroxide • cell migration • cell adhesion mediated by integrin • response to laminar fluid shear stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8754	11502
Ensembl	ENSG00000168615 ENSG00000282230	ENSMUSG00000031555
UniProt	Q13443	Q61072
RefSeq (mRNA)	NM_001005845 NM_003816	NM_001270996 NM_007404
RefSeq (protein)	NP_003807	NP_001257925 NP_031430
Location (UCSC)	Chr 8: 39 – 39.11 Mb	Chr 8: 24.95 – 25.02 Mb
PubMed search

1M1V

8754

11502

ENSG00000168615
ENSG00000282230

ENSMUSG00000031555

Q13443

Q61072

NM_001005845
NM_003816

NM_001270996
NM_007404

NP_003807

NP_001257925
NP_031430

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.

...
Wikipedia