ACVR2B

ACVR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QLU, 4FAO, 2H62
Identifiers
Aliases	ACVR2B, ACTRIIB, ActR-IIB, HTX4, activin A receptor type 2B
External IDs	OMIM: 602730 MGI: 87912 HomoloGene: 863 GeneCards: ACVR2B
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • signal transducer, downstream of receptor, with serine/threonine kinase activity • growth factor binding • activin binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • protein binding • protein serine/threonine/tyrosine kinase activity • activin receptor activity, type II • ATP binding Cellular component • cytoplasm • integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane • protein complex Biological process • pattern specification process • skeletal system development • palate development • regulation of transcription, DNA-templated • organ growth • embryonic foregut morphogenesis • signal transduction by protein phosphorylation • kidney development • lymphangiogenesis • lung development • positive regulation of bone mineralization • retina vasculature development in camera-type eye • phosphorylation • lymphatic endothelial cell differentiation • skeletal system morphogenesis • gastrulation with mouth forming second • insulin secretion • negative regulation of transcription from RNA polymerase II promoter • response to glucose • post-embryonic development • BMP signaling pathway • venous blood vessel development • odontogenesis of dentin-containing tooth • protein phosphorylation • heart development • blood vessel remodeling • determination of left/right symmetry • positive regulation of osteoblast differentiation • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of activin receptor signaling pathway • regulation of signal transduction • artery development • pancreas development • mesoderm development • activation of protein kinase activity • signal transduction • anterior/posterior pattern specification • activin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	93	11481
Ensembl	ENSG00000114739	ENSMUSG00000061393
UniProt	Q13705	P27040
RefSeq (mRNA)	NM_001106	NM_007397 NM_001313757
RefSeq (protein)	NP_001097	NP_031423.1 NP_001300686.1 NP_001300686 NP_031423
Location (UCSC)	Chr 3: 38.45 – 38.49 Mb	Chr 9: 119.4 – 119.43 Mb
PubMed search

2QLU, 4FAO, 2H62

93

11481

ENSG00000114739

ENSMUSG00000061393

Q13705

P27040

NM_001106

NM_007397
NM_001313757

NP_001097

NP_031423.1
NP_001300686.1
NP_001300686
NP_031423

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

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Wikipedia