ACTG1

ACTG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JLH
Identifiers
Aliases	ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
External IDs	MGI: 87906 HomoloGene: 74402 GeneCards: ACTG1
Gene ontology Molecular function • nucleotide binding • protein binding • ATP binding • ubiquitin protein ligase binding • identical protein binding • structural constituent of cytoskeleton Cellular component • focal adhesion • nucleus • dense body • cytoplasm • membrane • cytosol • extracellular exosome • blood microparticle • plasma membrane • cytoskeleton • extracellular matrix • extracellular space Biological process • movement of cell or subcellular component • cell junction assembly • ephrin receptor signaling pathway • platelet aggregation • Fc-gamma receptor signaling pathway involved in phagocytosis • retina homeostasis • vascular endothelial growth factor receptor signaling pathway • cytoskeleton organization • response to mechanical stimulus • response to calcium ion • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	71	11465
Ensembl	ENSG00000184009	ENSMUSG00000062825
UniProt	P63261	P63260
RefSeq (mRNA)	NM_001199954 NM_001614	NM_009609 NM_001313923
RefSeq (protein)	NP_001186883 NP_001605	NP_033739.1 NP_001300852 NP_033739
Location (UCSC)	Chr 17: 81.51 – 81.52 Mb	Chr 11: 120.35 – 120.35 Mb
PubMed search

5JLH

71

11465

ENSG00000184009

ENSMUSG00000062825

P63261

P63260

NM_001199954
NM_001614

NM_009609
NM_001313923

NP_001186883
NP_001605

NP_033739.1
NP_001300852
NP_033739

Gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells. Mutations in ACTG1 have been associated with nonsyndromic hearing loss and Baraitser-Winter syndrome, as well as susceptibility of adolescent patients to vincristine toxicity.

...
Wikipedia