ACTB

ACTB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BYH, 3D2U, 3J82, 3LUE
Identifiers
Aliases	ACTB, BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
External IDs	MGI: 87904 HomoloGene: 110648 GeneCards: ACTB
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • nucleotide binding • nitric-oxide synthase binding • Tat protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • structural constituent of cytoskeleton • protein binding • kinesin binding • identical protein binding • nucleosomal DNA binding • ATP binding Cellular component • cytoplasm • blood microparticle • membrane • focal adhesion • NuA4 histone acetyltransferase complex • plasma membrane • intracellular ribonucleoprotein complex • nucleoplasm • protein complex • nuclear chromatin • cytoplasmic ribonucleoprotein granule • extracellular exosome • cytoskeleton • dense body • cortical cytoskeleton • cytosol • myelin sheath • extracellular space Biological process • positive regulation of gene expression, epigenetic • movement of cell or subcellular component • substantia nigra development • Fc-gamma receptor signaling pathway involved in phagocytosis • ephrin receptor signaling pathway • ATP-dependent chromatin remodeling • retina homeostasis • vascular endothelial growth factor receptor signaling pathway • platelet aggregation • cell junction assembly • cytoskeleton organization • protein deubiquitination • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	60	11461
Ensembl	ENSG00000075624	ENSMUSG00000029580
UniProt	P60709	P60710
RefSeq (mRNA)	NM_001101	NM_007393
RefSeq (protein)	NP_001092	NP_031419.1 NP_031419
Location (UCSC)	Chr 7: 5.53 – 5.56 Mb	Chr 5: 142.9 – 142.91 Mb
PubMed search

3BYH, 3D2U, 3J82, 3LUE

60

11461

ENSG00000075624

ENSMUSG00000029580

P60709

P60710

NM_001101

NM_007393

NP_001092

NP_031419.1
NP_031419

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

Beta-actin has been shown to interact with SPTBN2. In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

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Wikipedia