SPTBN2

SPTBN2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WJM, 1WYQ
Identifiers
Aliases	SPTBN2, GTRAP41, SCA5, SCAR14, spectrin beta, non-erythrocytic 2
External IDs	MGI: 1313261 HomoloGene: 48482 GeneCards: SPTBN2
Gene ontology Molecular function • actin binding • phospholipid binding • structural constituent of cytoskeleton • Ras guanyl-nucleotide exchange factor activity • cadherin binding Cellular component • cell junction • neuronal cell body • cell cortex • apical plasma membrane • cytoskeleton • spectrin • extracellular space • cytoplasm • cytosol Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class II • multicellular organism growth • MAPK cascade • axon guidance • cerebellar Purkinje cell layer morphogenesis • ER to Golgi vesicle-mediated transport • adult behavior • actin filament capping • synapse assembly • vesicle-mediated transport • cytoskeleton organization • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6712	20743
Ensembl	ENSG00000173898	ENSMUSG00000067889
UniProt	O15020	n/a
RefSeq (mRNA)	NM_006946	NM_021287
RefSeq (protein)	NP_008877	n/a
Location (UCSC)	Chr 11: 66.69 – 66.73 Mb	Chr 19: 4.71 – 4.75 Mb
PubMed search

1WJM, 1WYQ

6712

20743

ENSG00000173898

ENSMUSG00000067889

O15020

n/a

NM_006946

NM_021287

NP_008877

n/a

Spectrin beta chain, brain 2 is a protein that in humans is encoded by the SPTBN2 gene.

Mutations in this gene is associated with Spinocerebellar ataxia type 5.

SPTBN2 has been shown to interact with:

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Wikipedia