ACOT2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3HLK

Identifiers

Aliases

ACOT2, CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128, acyl-CoA thioesterase 2

External IDs

MGI: 2159605 HomoloGene: 25661 GeneCards: ACOT2

Gene ontology
Molecular function	• thiolester hydrolase activity • palmitoyl-CoA hydrolase activity • carboxylic ester hydrolase activity • hydrolase activity • receptor binding • acyl-CoA hydrolase activity • myristoyl-CoA hydrolase activity
Cellular component	• extracellular exosome • mitochondrial matrix • mitochondrion
Biological process	• very long-chain fatty acid metabolic process • long-chain fatty acid metabolic process • acyl-CoA metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10965


171210

Ensembl


ENSG00000119673


ENSMUSG00000021226

UniProt


P49753


Q9QYR9

RefSeq (mRNA)


NM_006821


NM_134188

RefSeq (protein)


NP_006812


NP_598949

Location (UCSC)

Chr 14: 73.57 – 73.58 Mb

Chr 12: 83.99 – 83.99 Mb

PubMed search

Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.

Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze Coenzyme A (CoA) esters, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA. ACOT2 shows high acyl-CoA thioesterase activity on medium- and long-chain acyl-CoAs, with an optimal pH of 8.5. It is most active on myristoyl-CoA but also shows high activity on palmitoyl-CoA, stearoyl-CoA, and arachidoyl-CoA.

The protein encoded by the ACOT2 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A esters of various molecules to the free acid plus CoA. These enzymes have also been referred to in the literature as acyl-CoA hydrolases, acyl-CoA thioester hydrolases, and palmitoyl-CoA hydrolases. The reaction carried out by these enzymes is as follows:

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Wikipedia