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ACE inhibitor and thiazide combination

Quinapril/hydrochlorothiazide
Combination of
Quinapril Angiotensin converting enzyme inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
Trade names Accuretic
AHFS/Drugs.com Multum Consumer Information
Pregnancy
category
  • US: D (Evidence of risk)
ATC code
Legal status
Legal status
Identifiers
ChemSpider
Lisinopril/hydrochlorothiazide
Combination of
Lisinopril ACE inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
MedlinePlus a601070
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • ℞ (Prescription only)
  
Fosinopril/hydrochlorothiazide
Combination of
Fosinopril Angiotensin converting enzyme inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
Trade names Monopril HCT
Pregnancy
category
  • C (1st trimester); D (2nd & 3rd trimesters)
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • ℞ (Prescription only)

An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by oral administration.

Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its significant risk to cause fetal/neonatal morbidity and mortality when being used during pregnancy (2nd and 3rd trimesters).

FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."


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