ABCB11

ABCB11
Identifiers
Aliases	ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP, ATP binding cassette subfamily B member 11
External IDs	OMIM: 603201 MGI: 1351619 HomoloGene: 74509 GeneCards: ABCB11
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 168,922,938 bp End 169,031,322 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band n/a Start 69,238,282 bp End 69,342,616 bp
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • bile acid-exporting ATPase activity • transporter activity • canalicular bile acid transmembrane transporter activity • ATPase activity • sodium-exporting ATPase activity, phosphorylative mechanism • ATP binding Cellular component • integral component of membrane • plasma • apical part of cell • integral component of plasma membrane • intercellular canaliculus • extracellular exosome • membrane Biological process • canalicular bile acid transport • transmembrane transport • bile acid biosynthetic process • sodium ion transmembrane transport • bile acid and bile salt transport • ATP hydrolysis coupled cation transmembrane transport • ATP hydrolysis coupled anion transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8647	27413
Ensembl	ENSG00000276582 ENSG00000073734	ENSMUSG00000027048
UniProt	O95342	Q9QY30
RefSeq (mRNA)	NM_003742	NM_021022
RefSeq (protein)	NP_003733	NP_066302
Location (UCSC)	Chr 2: 168.92 – 169.03 Mb	Chr 2: 69.24 – 69.34 Mb
PubMed search

8647

27413

ENSG00000276582
ENSG00000073734

ENSMUSG00000027048

O95342

Q9QY30

NM_003742

NM_021022

NP_003733

NP_066302

ATP-binding cassette, sub-family B member 11 also known as ABCB11 is a protein which in humans is encoded by the ABCB11 gene.

The product of the ABCB11 gene is an ABC transporter named BSEP (Bile Salt Export Pump), or sPgp (sister of P-glycoprotein). This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).

This protein is a member of the MDR/TAP subfamily. Some members of the MDR/TAP subfamily are involved in multidrug resistance. This particular protein is responsible for the transport of taurocholate and other cholate conjugates from (liver cells) to the bile. In humans, the activity of this transporter is the major determinant of bile formation and bile flow.

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Wikipedia