AANAT (gene)

AANAT
Identifiers
Aliases	AANAT, DSPS, SNAT, aralkylamine N-acetyltransferase
External IDs	MGI: 1328365 HomoloGene: 31013 GeneCards: AANAT
Gene ontology Molecular function • transferase activity • N-acetyltransferase activity • 14-3-3 protein binding • arylamine N-acetyltransferase activity • protein binding • transferase activity, transferring acyl groups • aralkylamine N-acetyltransferase activity Cellular component • cytoplasm • perinuclear region of cytoplasm • cytosol Biological process • melatonin biosynthetic process • response to cytokine • response to organic cyclic compound • photoperiodism • response to copper ion • rhythmic process • response to corticosterone • response to zinc ion • indolalkylamine biosynthetic process • response to calcium ion • response to insulin • response to prostaglandin E • circadian rhythm • N-terminal protein amino acid acetylation • response to cAMP • cellular response to cAMP • response to light stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	15	11298
Ensembl	ENSG00000129673	ENSMUSG00000020804
UniProt	Q16613	O88816
RefSeq (mRNA)	NM_001088 NM_001166579	NM_009591
RefSeq (protein)	NP_001079 NP_001160051	NP_033721
Location (UCSC)	Chr 17: 76.45 – 76.47 Mb	Chr 11: 116.59 – 116.6 Mb
PubMed search

15

11298

ENSG00000129673

ENSMUSG00000020804

Q16613

O88816

NM_001088
NM_001166579

NM_009591

NP_001079
NP_001160051

NP_033721

AANAT is a gene that encodes an enzyme aralkylamine N-acetyltransferase. It is the key regulator of day-night cycle (circadian rhythm). It is found in all animals. In humans it is present on chromosome 17, in chimpanzees chromosome 17, in mouse and sheep chromosome 11, in rat chromosome 10, and in chicken chromosome 18.

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation.

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