The A57 is a major road in England. It runs east from Liverpool to Lincoln, via Warrington, Cadishead, Irlam, Patricroft, Eccles, Salford and Manchester, then through the Pennines over the Snake Pass (between the high moorlands of Bleaklow and Kinder Scout), around the Ladybower Reservoir, through Sheffield and past Worksop. Within Manchester a short stretch becomes the A57(M) motorway (the Mancunian Way).
The 3-mile (4.8 km) £4 million Aston relief road in Sheffield opened in mid-1985, with the old route now designated as the B6200.
The A57 begins at The Strand (A5036) near the River Mersey, as part of Water Street. It forms an east–west route through the north of the city centre with another one-way road system as Tithebarn Street (passing part of JMU), Great Crosshall Street and Churchill Way in the east direction and Churchill Way and Dale Street in the west direction. The connecting roads Moorfields and Hatton Garden are also part of the A57, which join the east and west directions. In both directions, Churchill Way crosses the A59 near the entrance of the Queensway Tunnel. It overlaps briefly with the A580 as Islington, separated as two one-way roads, then becomes Prescot Street, passing the Royal Liverpool University Hospital. At the junction with the B5340, it becomes Kensington, meeting the A5089 to the south and B5188 to the north, becoming Prescot Road. It crosses a railway at Fairfield passing St Anne's Church on the left near the Stanley public house, overlapping with the B5189 Green Lane to the north. It meets the A5047 to the south near a Tesco and the B5189 at Old Swan. At the junction with the A5058 Queens Drive it enters Knotty Ash (with Alder Hey Children's Hospital to the north), becoming East Prescot Road and a trunk road. There is a roundabout and it enters Dovecot before it passes through Huyton. It meets the A526 Seth Powell Way to the north (for the M57), becoming Liverpool Road, At junction two of the M57, it meets the B5194 Knowsley Lane to the north and B5199 Huyton Lane to the south, and the start of the A58. It passes through Prescot as the non-trunk Derby Street then High Street. It meets the A58 again and becomes a trunk road, then meets the B5200 (former route of the A57) at a roundabout, becoming Warrington Road. It crosses the Liverpool to Wigan Line near Scotchbarn Leisure Centre. It meets the B5201 to the north opposite Whiston Hospital. It passes through Rainhill, meeting the B5413 near the railway station. It passes Rainhill High School to the left, then St Bartholomew RC Primary School. At junction 7 of the M62, it meets the A557 (for Widnes) and the St Helens Linkway A570 (for St Helens). The road runs along the road from junction 7 for about 1 mile (1.6 km), then it meets the B5419 at a crossroads, and the A569 to the left at Bold Heath near the Griffin Inn. At Lingley Green it enters as Liverpool Road, passing the Trigger Pond pub on the left. It crosses the Liverpool to Manchester Line (southern route). At Great Sankey, it becomes a dual-carriageway and meets the A562 at a roundabout.