5HT2C receptor

HTR2C
Identifiers
Aliases	HTR2C, 5-HT2C, 5-5HTR1C, 5-HT1C, 5-HT2C receptor, 5-hydroxytryptamine receptor 2C
External IDs	MGI: 96281 HomoloGene: 20242 GeneCards: HTR2C
Gene location (Human) Chr. X chromosome (human) Band n/a Start 114,584,078 bp End 114,910,061 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band n/a Start 146,962,513 bp End 147,197,277 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • G-protein coupled receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • drug binding • Gq/11-coupled serotonin receptor activity • serotonin binding • neurotransmitter receptor activity Cellular component • integral component of membrane • membrane • plasma • integral component of plasma membrane Biological process • release of sequestered calcium ion into cytosol • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • phospholipase C-activating serotonin receptor signaling pathway • behavior • locomotory behavior • positive regulation of phosphatidylinositol biosynthetic process • cellular calcium ion homeostasis • behavioral fear response • regulation of neurological system process • cGMP biosynthetic process • phospholipase C-activating G-protein coupled receptor signaling pathway • serotonin receptor signaling pathway • feeding behavior • positive regulation of ERK1 and ERK2 cascade • regulation of corticotropin-releasing hormone secretion • regulation of appetite • positive regulation of fat cell differentiation • response to drug • signal transduction • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3358	15560
Ensembl	ENSG00000147246	ENSMUSG00000041380
UniProt	P28335	P34968
RefSeq (mRNA)	NM_001256761 NM_000868 NM_001256760	NM_008312
RefSeq (protein)	NP_000859 NP_001243689 NP_001243690	NP_032338
Location (UCSC)	Chr X: 114.58 – 114.91 Mb	Chr X: 146.96 – 147.2 Mb
PubMed search

3358

15560

ENSG00000147246

ENSMUSG00000041380

P28335

P34968

NM_001256761
NM_000868
NM_001256760

NM_008312

NP_000859
NP_001243689
NP_001243690

NP_032338

The 5-HT_2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to G_q/G₁₁ and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, that in humans is located at the X chromosome. As males have one copy of the gene and in females one of the two copies of the gene is repressed, polymorphisms at this receptor can affect the two sexes to differing extent.

...
Wikipedia