5-HT2B

HTR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NC3, 4IB4
Identifiers
Aliases	HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
External IDs	MGI: 109323 HomoloGene: 55492 GeneCards: HTR2B
Gene ontology Molecular function • G-protein coupled receptor activity • GTPase activator activity • signal transducer activity • G-protein coupled serotonin receptor activity • drug binding • G-protein alpha-subunit binding • serotonin binding • neurotransmitter receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • synapse • cell junction • neuron projection • integral component of plasma membrane Biological process • intestine smooth muscle contraction • smooth muscle contraction • G-protein coupled receptor internalization • G-protein coupled receptor signaling pathway • release of sequestered calcium ion into cytosol • regulation of behavior • positive regulation of endothelial cell proliferation • behavior • positive regulation of MAP kinase activity • phosphorylation • positive regulation of cytokine production • vasoconstriction • ERK1 and ERK2 cascade • positive regulation of cytokine secretion • positive regulation of phosphatidylinositol biosynthetic process • cardiac muscle hypertrophy • heart morphogenesis • cellular calcium ion homeostasis • neural crest cell differentiation • negative regulation of apoptotic process • negative regulation of cell death • activation of phospholipase C activity • protein kinase C signaling • cGMP biosynthetic process • cellular response to temperature stimulus • positive regulation of GTPase activity • heart development • positive regulation of nitric-oxide synthase activity • protein kinase C-activating G-protein coupled receptor signaling pathway • embryonic morphogenesis • serotonin receptor signaling pathway • neural crest cell migration • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • phosphatidylinositol 3-kinase signaling • negative regulation of autophagy • positive regulation of cell division • response to drug • calcium-mediated signaling • signal transduction • phospholipase C-activating G-protein coupled receptor signaling pathway • G-protein coupled serotonin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3357	15559
Ensembl	ENSG00000135914	ENSMUSG00000026228
UniProt	P41595	Q02152
RefSeq (mRNA)	NM_000867 NM_001320758	NM_008311
RefSeq (protein)	NP_000858 NP_001307687	NP_032337.2 NP_032337
Location (UCSC)	Chr 2: 231.11 – 231.13 Mb	Chr 1: 86.1 – 86.11 Mb
PubMed search

4NC3, 4IB4

3357

15559

ENSG00000135914

ENSMUSG00000026228

P41595

Q02152

NM_000867
NM_001320758

NM_008311

NP_000858
NP_001307687

NP_032337.2
NP_032337

5-Hydroxytryptamine receptor 2B (5-HT_2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene. 5-HT_2B is a member of the 5-HT₂ receptor family that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

The 5-HT₂ receptors (of which the 5-HT_2B receptor is a subtype) mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of hallucinogenic substituted amphetamines.

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Wikipedia