4,4'-Dimethylaminorex

4,4'-DMAR
Clinical data

ATC code	none
Legal status
Legal status	DE: Anlage II (Prohibited) UK: Class A Illegal in Czech Republic and Sweden
Identifiers
IUPAC name 4-Methyl-5-(methylphenyl)-4,5-dihydro-1,3-oxazol-2-amine
CAS Number	1445569-01-6^Y
PubChem (CID)	20741615
ChemSpider	19546433
UNII	18Y239214S^Y
Chemical and physical data
Formula	C₁₁H₁₄N₂O
Molar mass	190.24 g/mol
3D model (Jmol)	Interactive image
SMILES CC(N=C(N)O1)C1C2=CC=C(C)C=C2
InChI InChI=1S/C11H14N2O/c1-7-3-5-9(6-4-7)10-8(2)13-11(12)14-10/h3-6,8,10H,1-2H3,(H2,12,13) Key:NPILLHMQNMXXTL-UHFFFAOYSA-N

4,4'-Dimethylaminorex (abbreviated as 4,4'-DMAR), sometimes referred to by the street name "Serotoni", is a psychostimulant and entactogen designer drug related to aminorex, 4-methylaminorex and pemoline. It was first detected in the Netherlands in December 2012, and has been sold as a designer drug around Europe since mid-2013.

4,4'-DMAR had been linked to at least 31 deaths in Hungary, Poland and the UK by February 2014, mostly when consumed in combination with other drugs. Nineteen deaths linked to 4,4'-DMAR were reported in Northern Ireland in the same time period.

4,4'-DMAR acts as a potent and balanced serotonin-norepinephrine-dopamine releasing agent (SNDRA), with EC₅₀ values for serotonin, norepinephrine, and dopamine release of 18.5 nM, 26.9 nM, and 8.6 nM, respectively.

The UK Home Office expressed intent to ban 4,4'-DMAR following advice from the Advisory Council on the Misuse of Drugs and subsequently it became a class A drug on 11 March 2015.

4,4'-DMAR is an Anlage II controlled substance in Germany as of May 2015.

Sweden's public health agency suggested to classify 4,4'-DMAR as hazardous substance on November 10, 2014.

4,4'-DMAR is also banned in the Czech Republic.

...
Wikipedia