3α-hydroxysteroid dehydrogenase

AKR1C4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2FVL

Identifiers

Aliases

AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1, member C4, aldo-keto reductase family 1 member C4

External IDs

MGI: 1933427 HomoloGene: 84695 GeneCards: AKR1C4

EC number

1.1.1.225

Gene ontology
Molecular function	• retinal dehydrogenase activity • aldo-keto reductase (NADP) activity • bile acid transmembrane transporter activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • chlordecone reductase activity • electron carrier activity • oxidoreductase activity • androsterone dehydrogenase activity
Cellular component	• cytoplasm • cytosol • extracellular exosome
Biological process	• cellular response to jasmonic acid stimulus • steroid metabolic process • daunorubicin metabolic process • doxorubicin metabolic process • androgen metabolic process • retinoid metabolic process • bile acid and bile salt transport • bile acid biosynthetic process • oxidation-reduction process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1109


83702

Ensembl


ENSG00000198610


ENSMUSG00000021210

UniProt


P17516


P70694

RefSeq (mRNA)


NM_001818


NM_030611

RefSeq (protein)


NP_001809


NP_085114.1 NP_085114

Location (UCSC)

Chr 10: 5.2 – 5.22 Mb

Chr 13: 4.43 – 4.46 Mb

PubMed search

NP_085114.1
NP_085114

3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to be necessary for the synthesis of the endogenous neurosteroids allopregnanolone, THDOC, and 3α-androstanediol. It is also known to catalyze the reversible conversion of 3α-androstanediol (5α-androstane-3α,17β-diol) to dihydrotestosterone (DHT) (5α-androstan-17β-ol-3-one) and vice versa.

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