The 2011 Major League Baseball All-Star Game was the 82nd in-season exhibition game between the All-Stars of the National League (NL) and the American League (AL); the leagues composing Major League Baseball. The event was held on Tuesday, July 12, 2011 at Chase Field in Phoenix, Arizona, home of the National League Arizona Diamondbacks. The game ended in a 5–1 win for the National League, their second straight All-Star victory. It was the first MLB All-Star Game to be held in Arizona and the first in a National League Park to have a designated hitter.

With a combination of injuries and rule enforcements, a record 84 players were named to the All-Star rosters. This broke the record of 82 players that were on rosters for the 2010 game.

As with each All-Star Game since 1970, the nine starting position players of each league were elected by fan balloting. The remaining players were selected by a players' vote, each league's team manager, and a second fan balloting to add one more player to each roster. In all, 32 players were selected to each league's team, not including players who decline to play due to injuries or personal reasons.

Diamondbacks manager Bob Melvin confirmed on April 10, 2009 that Arizona would host the 2011 All-Star Game and it was officially announced by Commissioner Bud Selig the next day. Phoenix had never hosted the All-Star Game before, the last first-time host city was Denver, Colorado in 1998. The game was the ninth straight All-Star Game to decide home-field advantage in the World Series. Prior All-Star games had only used the designated hitter (DH) rule when in American League parks. However, the 2011 game was the first to feature a DH in a NL park following a rules change in 2010. The NL came into the game having won the previous year's match, their first victory since 1996.

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