The 2010 Major League Baseball All-Star Game was the 81st midseason exhibition between the All-Stars of the American League (AL) and the National League (NL), the two leagues comprising Major League Baseball. The game was held on July 13, 2010, at Angel Stadium of Anaheim, the home of the American League Los Angeles Angels of Anaheim, and was telecast by Fox Sports in the USA, with Joe Buck and Tim McCarver in the broadcast booth. Fox also teamed with DirecTV to produce a separate 3D broadcast, the first ever for a network Major League Baseball game. Kenny Albert and Mark Grace called the 3D telecast.ESPN Radio also broadcast the game, with Jon Sciambi and Dave Campbell announcing. The National League won the game 3–1, ending a 13-game winless streak.

This was the third All-Star Game hosted by the city of Anaheim, California, which previously hosted the game in 1967 and 1989. Since 2003, the winning team has earned home field advantage for the World Series. This is the first All Star Game the National League won since 1996, giving the NL said advantage in the World Series for the first time since 2001 – ironically, the winning pitcher, Washington Nationals closer Matt Capps, would go on to participate in the American League playoffs after his trade to the Minnesota Twins just a couple of weeks following the Midsummer Classic.

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