The 2011–12 Spanish football season is Sevilla Fútbol Club's 11th consecutive season in La Liga and eighth consecutive playing European competitions since its participation in the 2004–05 UEFA Cup, despite the earlier fall in the Fourth Qualifying Round in August. The team manager in the previous season, Gregorio Manzano, did not continue in the club. During the summer of 2011, Sevilla signed Marcelino as new manager after he unilaterally severed his contract with Racing de Santander. On 6 February, after losing 1–2 at home against Villarreal and after Sevilla earned just two points in its previous seven matches, he was sacked and replaced with Míchel. Finishing in ninth, the team did not qualify for European competition for the first time since 2004.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

On 6 November 2010, Sevilla's medical services discovered a strange injury in Tiberio Guarente's leg that required treatment. This injury caused that the Italian player was more than 6 months out of the stadiums. He officially played for first time after his injury in San Mamés, against Athletic Bilbao on 8 April 2012, 531 days after his last match.

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