The 2010–11 Spanish football season is Sevilla Fútbol Club's tenth consecutive season in La Liga. The team manager for the previous season, Antonio Álvarez, continued on the role until the 2–0 defeat against Hércules on 26 September 2010. After the match, Gregorio Manzano was appointed manager, assisted by former player Javier Navarro.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

On 1 January 2010, Sevilla's medical services detected some cardiac pathology in Sergio Sánchez's heart and they recommended to him to stop his activity with the team. On May 2010, he was surgical operated in Hamburg, Germany, and received orders of resting during six or seven months, when there will be valued (beginning of 2011) the possibility of returning to play football. On 27 December 2010, doctors at Vall d'Hebrón Hospital in Barcelona had officially told Sevilla that Sánchez has passed the latest tests about his recovery because of the surgical operation, so he can play football again from 2011.

On 16 September 2010, in the Europa League match against Paris Saint-Germain, Jesús Navas twisted his left ankle. He had to be replaced during that match because he couldn't walk as usual. His injury didn't appear serious, and he was considered recovered and fit to play in the pre-game Europa League against Borussia Dortmund at the Westfalenstadion. He had to be replaced on 76' because of a strong relapse. He was replaced by Julien Escudé. During October, it was thought that he needed surgery. He submitted it on 1 November in Vitoria-Gasteiz. He was operated by Dr. Mikel Sánchez and could return to play after Christmas, on 2 January against Osasuna.

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