2006 Big Ten football standings
	Conf				Overall
Team		W		L		W		L
#2 Ohio State $		8	–	0		12	–	1
#7 Wisconsin		7	–	1		12	–	1
#8 Michigan %		7	–	1		11	–	2
#24 Penn State		5	–	3		9	–	4
Purdue		5	–	3		8	–	6
Minnesota		3	–	5		6	–	7
Indiana		3	–	5		5	–	7
Iowa		2	–	6		6	–	7
Northwestern		2	–	6		4	–	8
Michigan State		1	–	7		4	–	8
Illinois		1	–	7		2	–	10

$ – BCS representative as conference champion % – BCS at-large representative Rankings from AP Poll

	1	2	3	4	Total
Indiana St	7	14	7	7	35
• Purdue	23	3	14	20	60

Date: September 2
Location: Ross-Ade Stadium, West Lafayette, Indiana

	1	2	3	4	Total
Miami (OH)	0	3	14	14	31
• Purdue	0	10	7	21	38

Date: September 9
Location: Ross-Ade Stadium, West Lafayette, Indiana

	1	2	3	4	Total
Ball St	10	0	3	15	28
• Purdue	7	14	10	7	38

Date: September 16
Location: Ross-Ade Stadium, West Lafayette, Indiana

	1	2	3	4	Total
Minnesota	7	0	7	7	21
• Purdue	3	7	10	7	27

Date: September 23
Location: Ross-Ade Stadium, West Lafayette, Indiana

	1	2	3	4	Total
Purdue	7	7	0	7	21
• Notre Dame	14	14	7	0	35

Date: September 30
Location: Notre Dame Stadium, South Bend, Indiana
Television network: NBC

	1	2	3	4	Total
Purdue	0	3	14	0	17
• Iowa	14	6	14	13	47

Date: October 7
Location: Kinnick Stadium, Iowa City, Iowa

	1	2	3	4	Total
• Purdue	7	10	7	7	31
Northwestern	7	3	0	0	10

Date: October 14
Location: Ryan Field, Evanston, Illinois

	1	2	3	4	Total
• Wisconsin	0	10	7	7	24
Purdue	3	0	0	0	3

Date: October 21
Location: Ross-Ade Stadium, West Lafayette, Indiana

The 2006 Purdue Boilermakers football team represented Purdue University during the 2006 NCAA Division I FBS football season. The team was coached by Joe Tiller and played its home games at Ross–Ade Stadium. Purdue played thirteen games in the 2006 season, finishing with an 8–6 record and a loss in the 2006 Champs Sports Bowl to Maryland.

Purdue entered 2005 highly ranked and as a dark horse candidate to win the Big 10 before losing six straight and falling to 2–6 after a blowout loss to Penn State. While the Boilermakers finished the 2005 season 5–6, the team closed out the year on a three-game winning streak. Purdue's coaching staff experienced several changes in the off-season. Jim Chaney, the offensive coordinator, left for a position with the St. Louis Rams of the NFL. Bill Legg and Ed Zaunbrecher succeeded Chaney as dual offensive coordinators. The Boilermakers returned seven starters on offense and four on defense. The condition of Ross–Ade Stadium's turf became a major issue in the 2005 season. A permanent sod of Bermuda grass was laid down in the off-season to replace the old turf.

Purdue opened up the 2006 campaign with a win over Division 1-AA opponent Indiana State Purdue paid tribute to the 1966 Rose Bowl championship team by wearing throwback jerseys. The Boilermakers dominated the first quarter with touchdown runs by Kory Sheets and Curtis Painter and a safety sandwiched in between the running scores. The Sycamores of Indiana State then got on the board with a touchdown run by quarterback Reilly Murphy. Painter then completed a touchdown pass to Dorien Bryant to close out the first quarter scoring. Indiana St. took advantage of a special teams miscue by Purdue when they returned a punt for a touchdown. Purdue got a field goal from Chris Summers before the blocked punt in the second quarter. Indiana State also scored a rushing touchdown right before halftime. Painter and Sheets both scored rushing touchdowns in the third quarter, while Sycamores running back Tony West scored his second rushing touchdown of the day. Purdue blew open the game in the fourth quarter with three straight touchdowns. Kory Sheets scored his third rushing touchdown and Bryant caught two more TD passes from Painter. Indiana State capped off the scoring with two seconds left in the game when Murphy tossed a touchdown pass to receiver Brian Jackson.

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