2006 Australian Open – Women's Singles
| Women's Singles | |
|---|---|
| 2006 Australian Open | |
| Champion |
 Amélie Mauresmo
|
| Runner-up |
 Justine Henin-Hardenne
|
| Final score | 6–1, 2–0 ret. |
Serena Williams was the defending champion, but she lost in the third round to Daniela Hantuchová.
Amélie Mauresmo, the third seed, ultimately won the tournament, her first major championship. Her finals opponent, eighth-seeded Justine Henin-Hardenne, retired down 2–0 in the second set, already down a set. Henin was suffering from stomach cramps resulting from the accidental misuse of anti-inflammatories for a chronic shoulder injury. This was the third match Mauresmo played during the tournament where her opponent retired.
Mauresmo and Henin would have a rematch in the final of Wimbledon, where Mauresmo would win in three sets.
This tournament was notable as it was the Grand Slam in which Martina Hingis made her comeback after a three-year absence from the WTA Tour, and the first Grand Slam in which future World No. 1 and two-times Australian Open champion Victoria Azarenka competed in the main draw.
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