2001 US Open - Men's Singles
| Men's Singles | |
|---|---|
| 2001 US Open | |
| Champion |
 Lleyton Hewitt
|
| Runner-up |
 Pete Sampras
|
| Final score | 7–6(7–4), 6–1, 6–1 |
Marat Safin was the defending champion, but lost in the semifinals to Pete Sampras. Lleyton Hewitt defeated Sampras 7–6(7–4), 6–1, 6–1 in the final to win the Men's Singles title at the 2001 US Open.
Former champion Pat Rafter made his final grand slam singles appearance, losing in the fourth round to Sampras.
This was the first time the US Open used 32 seeds instead of 16, in order to better spread out the higher ranked players.
The seeded players are listed below. Lleyton Hewitt is the champion; others show the round in which they were eliminated.
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