2000 US Open – Men's Singles
| Men's Singles | |
|---|---|
| 2000 US Open | |
| Champion |
 Marat Safin
|
| Runner-up |
 Pete Sampras
|
| Final score | 6–4, 6–3, 6–3 |
Andre Agassi was the defending champion but lost in the second round to Arnaud Clément. Marat Safin defeated Pete Sampras 6–4, 6–3, 6–3 in the final to win the Men's Singles tennis title at the 2000 US Open.
The tournament was also notable for the first Grand Slam appearance of future World No. 1 and champion Andy Roddick competed in the main draw, and the first appearance of Roger Federer in a U.S Open Grand Slam.
The seeded players are listed below. Marat Safin is the champion; others show the round in which they were eliminated.
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