The 2000–01 NBA season was the Spurs' 25th season in the National Basketball Association, the 28th in San Antonio, and 34th season as a franchise. During the offseason, the Spurs signed free agents Derek Anderson and Danny Ferry. The Spurs continued to be among the NBA's elite winning 23 of their final 29 games, which included a nine-game winning streak in March to recapture the Midwest Division with a 58–24 record, while posting a league best 33–8 record at home. Tim Duncan and David Robinson were both selected for the 2001 NBA All-Star Game. In the first round of the playoffs, the Spurs would easily defeat the Minnesota Timberwolves in four games. In the semifinals, they beat the 5th-seeded Dallas Mavericks in five games to advance the Western Conference Finals. However, they were swept in four straight games by the 2nd-seeded and defending champion Los Angeles Lakers.

Following the season, Anderson was traded along with Steve Kerr to the Portland Trail Blazers, Avery Johnson signed as a free agent with the Denver Nuggets, Samaki Walker signed with the Los Angeles Lakers and Sean Elliott retired.

(1) San Antonio Spurs vs. (8) Minnesota Timberwolves

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