The 2001 NBA All-Star Game was an exhibition basketball game which was played on February 11, 2001 at the MCI Center in Washington, D.C., home of the Washington Wizards. This game was the 50th edition of the North American National Basketball Association (NBA) All-Star Game and was played during the 2000–01 NBA season.

Allen Iverson was named the game's Most Valuable Player after he rallied the East to garner an improbable 111–110 comeback victory over the West. The East trailed 95–74 with nine minutes left after the West dominated the first 39 minutes behind its superior size. Iverson sparked the comeback scoring 15 of his 25 points in the final nine minutes of the game. Stephon Marbury also helped the East by hitting two three-pointers in the final 53 seconds, including one with 28 seconds left, which proved to be the game-winner.

Kobe Bryant scored the most points for the West squad (19 points), which led by as much as twenty-one points before the team squandered the lead. Bryant, the NBA's leading scorer at the time, could have taken the last shot; instead, he threw a pass that resulted in a last-second miss by Tim Duncan.

The coach for the Western Conference team was Sacramento Kings head coach Rick Adelman. The Kings had a 31-15 record on February 11. The coach for the Eastern Conference team was Philadelphia 76ers head coach Larry Brown. The 76ers had a 36-14 record on February 11.

The rosters for the All-Star Game were chosen in two ways. The starters were chosen via a fan ballot. Two guards, two forwards and one center who received the highest vote were named the All-Star starters. The reserves were chosen by votes among the NBA head coaches in their respective conferences. The coaches were not permitted to vote for their own players. The reserves consist of two guards, two forwards, one center and two players regardless of position. If a player is unable to participate due to injury, the commissioner will select a replacement.

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