The Orioles won the series three games to one. Although the White Sox took Game 1 won by a score of 2–1, the Orioles came back to win the last three games of the series. The Orioles went on to defeat the Philadelphia Phillies in five games in the 1983 World Series. In the regular season the White Sox won the West Division by twenty games with a 99–63 record. The Orioles won the East Division by six games with a 98–64 record.

Baltimore won the series, 3–1.

Wednesday, October 5, 1983, at Memorial Stadium in Baltimore, Maryland

Playing in their first postseason game since the 1959 World Series, the White Sox jumped out to a 1–0 ALCS lead behind a complete-game victory by LaMarr Hoyt, the American League Cy Young Award winner. In the third, Rudy Law singled with two outs and after another single, scored the game's first run on a Tom Paciorek infield single off of Scott McGregor. After a 42-minute rain delay in the fourth inning, the White Sox made it 2–0 when Paciorek walked to lead off the sixth, moved to third when Greg Luzinski reached on an Eddie Murray error and scored when Rookie of the Year Ron Kittle grounded into a double play. In the bottom of the ninth, Tito Landrum doubled with two outs before Cal Ripken Jr. denied Hoyt's shutout with two outs in the bottom of the ninth by driving in Landrum with a single for the Orioles' only run.

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