The 1981 Major League Baseball All-Star Game was the 52nd playing of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on August 9, 1981, at Cleveland Stadium in Cleveland, Ohio, the home of the Cleveland Indians of the American League.

This was one of only two All-Star Games to be played outside of the month of July (the other being the second 1959 game). The game was originally to be played on July 14, but was cancelled due to the players' strike lasting from June 12 to July 31. It was then brought back as a prelude to the second half of the season, which began the following day. At 72,086 people in attendance, it broke the stadium's own record of 69,751 set in 1954, setting the still-standing record for the highest attendance in an All Star Game.

Cleveland Stadium set a new All-Star Game record by hosting its fourth (and ultimately, final) Midsummer Classic. By the time Indians played host to the All-Star Game for the fifth time in 1997, they had moved to Jacobs Field.

Players in italics have since been inducted into the National Baseball Hall of Fame.

The American League started with four shutout innings, two apiece by starter Jack Morris and Len Barker. Meanwhile, Fernando Valenzuela, only the second rookie pitcher to start an All-Star Game, pitched a scoreless first with two strikeouts. The AL got on the board in the second when Ken Singleton homered off Tom Seaver.

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