1980–81 FIBA European Cup Winner's Cup
| 1980–81 FIBA European Cup Winner's Cup | |
|---|---|
| League | FIBA European Cup Winner's Cup |
| Sport | Basketball |
| Finals | |
| Champions |
 Squibb Cantù
|
| Runners-up |  FC Barcelona |
The 1980–81 FIBA European Cup Winner's Cup was the fifteenth edition of FIBA's competition for European basketball national cup champions, running from 7 October 1980 to 18 March 1981. It was contested by 20 teams, two less than in the previous edition.
Squibb Cantù defeated FC Barcelona in the final held in Rome winning the European Cup Winner's Cup for a (European record) fourth time.
*Union Récréation Alexandria withdrew before the second leg and Moderne received a forfeit (2-0).
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