1959 U.S. National Championships – Women's Singles
| Women's Singles | |
|---|---|
| 1959 U.S. National Championships | |
| Champion |
 Maria Bueno
|
| Runner-up |
 Christine Truman
|
| Final score | 6–1, 6–4 |
First-seeded Maria Bueno defeated Christine Truman 6–1, 6–4 in the final to win the Women's Singles tennis title at the 1959 U.S. National Championships.
The seeded players are listed below. Maria Bueno is the champion; others show in brackets the round in which they were eliminated.
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