The IV edition of the Caribbean Series (Serie del Caribe) was played in 1952. It was held from February 20 through February 26, featuring the champion baseball teams of Cuba, Leones de la Habana; Panama, Carta Vieja Yankees; Puerto Rico, Senadores de San Juan and Venezuela, Cervecería Caracas. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Panama City. The first pitch was thrown by Alcibíades Arosemena, by then the President of Panama.
Cuba became the first country to win two Caribbean Series championships with an undefeated record of 5-0. The Cuban team, with manager/catcher Mike González at the helm, won the Series behind a strong pitching effort by Tommy Fine, who posted a 2-0 record with a 1.50 ERA in two complete-games and won Most Valuable Player honors. After a 3-3 tie against Puerto Rico in the Series opener, he was called by the Cuban team as a late replacement for future Hall of Famer Hoyt Wilhelm. Fine posted the only no-hitter pitched in any Caribbean series game, to give his team a 1-0 win against Venezuela. Five days later, Fine faced Panama's club and was close to glory. He was three outs from consecutive no-hitters in the series, having allowed a single in the ninth inning to break it up. His 17 hitless streak also is the longest in series history. Outfielder Sandy Amorós led series hitters with a .450 batting average (9-for-20), including personal numbers with a .650 SLG, six runs, six RBI. Other contributions came from OF Fernando Pedroso (.400), catcher Andrés Fleitas (.304), and infielders Lou Klein (.333) and Spider Jorgensen, who hit two of the team's three home runs.