The III edition of the Caribbean Series (Serie del Caribe) was played in 1951. The Series inauguration on February 21 was delayed due to heavy rain and it was held from February 22 through February 26, including two double-headers on February 25, featuring the champion baseball teams of Cuba, Leones del Habana; Panama, Spur Cola Colonites; Puerto Rico, Cangrejeros de Santurce, and Venezuela, Navegantes del Magallanes. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Cervecería Caracas Stadium in Caracas, Venezuela.
The Puerto Rico team won the Series with a 5-1 record and was managed by George Scales. Their only defeat came from Cuba. The team was led by OF Luis Rodríguez Olmo, who was named Most Valuable Player after hitting .423 (11-for-26) with three home runs and nine RBI. Other contributions came from pitchers Pantalones Santiago (two complete-game wins), Rubén Gómez (two wins, one save), 1B George Crowe (.333, one grand slam, 7 RBI), and SS Stan Breard (.423, seven runs, 4 doubles, 8 RBI). Also in the Puerto Rican roster were Jim Gilliam (2B), Buster Clarkson (3B), Bob Thurman (OF) and Willard Brown (OF).