14-3-3 epsilon

YWHAE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BR9, 3UAL, 3UBW
Identifiers
Aliases	YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
External IDs	MGI: 894689 HomoloGene: 100743 GeneCards: YWHAE
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.3 Start 1,344,272 bp End 1,400,378 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 45.92 cM Start 75,732,869 bp End 75,765,845 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion channel binding • protein domain specific binding • protein complex binding • histone deacetylase binding • potassium channel regulator activity • phosphoprotein binding • protein binding • MHC class II protein complex binding • protein heterodimerization activity • enzyme binding • poly(A) RNA binding • phosphoserine residue binding • ubiquitin protein ligase binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • cytosol • membrane • kinesin complex • focal adhesion • melanosome • axon • mitochondrion • extracellular exosome • cytoplasmic vesicle membrane • cell-cell adherens junction Biological process • protein targeting • negative regulation of protein dephosphorylation • intracellular signal transduction • substantia nigra development • neuron migration • negative regulation of peptidyl-serine dephosphorylation • hippo signaling • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • G2/M transition of mitotic cell cycle • regulation of heart rate by hormone • regulation of potassium ion transmembrane transporter activity • cerebral cortex development • regulation of cellular response to heat • regulation of membrane repolarization • membrane organization • viral process • regulation of heart rate by cardiac conduction • membrane repolarization during cardiac muscle cell action potential • hippocampus development • cell-cell adhesion • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7531	22627
Ensembl	ENSG00000274474 ENSG00000108953	ENSMUSG00000020849
UniProt	P62258	P62259
RefSeq (mRNA)	NM_006761	NM_009536
RefSeq (protein)	NP_006752	NP_033562
Location (UCSC)	Chr 17: 1.34 – 1.4 Mb	Chr 11: 75.73 – 75.77 Mb
PubMed search

2BR9, 3UAL, 3UBW

7531

22627

ENSG00000274474
ENSG00000108953

ENSMUSG00000020849

P62258

P62259

NM_006761

NM_009536

NP_006752

NP_033562

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

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