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11-beta-hydroxysteroid dehydrogenase type 2

HSD11B2
Identifiers
Aliases HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3, hydroxysteroid (11-beta) dehydrogenase 2, hydroxysteroid 11-beta dehydrogenase 2
External IDs OMIM: 614232 MGI: 104720 HomoloGene: 20088 GeneCards: HSD11B2
Gene location (Human)
Chromosome 16 (human)
Chr. Chromosome 16 (human)
Chromosome 16 (human)
Genomic location for HSD11B2
Genomic location for HSD11B2
Band 16q22.1 Start 67,430,652 bp
End 67,437,553 bp
RNA expression pattern
PBB GE HSD11B2 204130 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000196

NM_008289

RefSeq (protein)

NP_000187

NP_032315

Location (UCSC) Chr 16: 67.43 – 67.44 Mb Chr 8: 105.52 – 105.52 Mb
PubMed search

NM_000196

NM_008289

NP_000187

NP_032315

Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is encoded by the HSD11B2 gene.

Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD+-dependent enzyme expressed in aldosterone-selective epithelial tissues such as the kidney, colon, salivary and sweat glands. HSD211B2 expression is also found in the brainstem in a small, aldosterone-sensitive subset of neurons located in the nucleus of the solitary tract referred to as HSD2 neurons.

In these tissues, HSD11B2 oxidizes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. This protective mechanism is necessary because cortisol circulates at 100-1000-fold higher concentrations than aldosterone, and binds with equal affinity to the mineralocorticoid receptor, thereby out-competing aldosterone in cells that do not produce HSD11B2.


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