Αv integrins

ITGAV

PDB 1jv2 EBI.jpg

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9

Identifiers

ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V

External IDs

MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q32.1	Start	186,590,065 bp
Band	2q32.1	End	186,680,901 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2 D\|2 49.33 cM	Start	83,724,397 bp
Band	2 D\|2 49.33 cM	End	83,806,916 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transforming growth factor beta binding • metal ion binding • voltage-gated calcium channel activity • virus receptor activity • protein kinase C binding • protease binding • extracellular matrix protein binding • extracellular matrix binding • fibronectin binding • opsonin binding • insulin-like growth factor I binding • protein binding • fibroblast growth factor binding • neuregulin binding • coreceptor activity • C-X3-C chemokine binding • receptor binding • peptide binding
Cellular component	• lamellipodium membrane • integrin alphav-beta3 complex • extracellular exosome • alphav-beta3 integrin-IGF-1-IGF1R complex • integral component of membrane • integrin alphav-beta5 complex • membrane • integrin alphav-beta8 complex • ruffle membrane • integrin complex • microvillus membrane • filopodium membrane • external side of plasma membrane • phagocytic vesicle • plasma membrane • integral component of plasma membrane • cell surface • cytosol • focal adhesion • cell junction • specific granule membrane • integrin alphav-beta6 complex
Biological process	• regulation of phagocytosis • apoptotic cell clearance • endodermal cell differentiation • apolipoprotein A-I-mediated signaling pathway • negative chemotaxis • negative regulation of lipid storage • negative regulation of low-density lipoprotein particle receptor biosynthetic process • extracellular matrix organization • heterotypic cell-cell adhesion • positive regulation of cell migration • regulation of apoptotic cell clearance • substrate adhesion-dependent cell spreading • vascular endothelial growth factor receptor signaling pathway • cell-matrix adhesion • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • blood vessel development • negative regulation of entry of bacterium into host cell • integrin-mediated signaling pathway • calcium ion transmembrane transport • negative regulation of macrophage derived foam cell differentiation • negative regulation of extrinsic apoptotic signaling pathway • leukocyte migration • cell-substrate adhesion • entry of symbiont into host cell by promotion of host phagocytosis • negative regulation of lipoprotein metabolic process • negative regulation of lipid transport • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of cell adhesion • ERK1 and ERK2 cascade • cell growth • positive regulation of osteoblast proliferation • cell adhesion • angiogenesis • vasculogenesis • cellular calcium ion homeostasis • positive regulation of cytosolic calcium ion concentration • positive regulation of cell proliferation • cell migration • neutrophil degranulation • positive regulation of MAPK cascade • cell adhesion mediated by integrin • transforming growth factor-beta secretion • viral entry into host cell
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


3685


16410


ENSG00000138448


ENSMUSG00000027087


P06756


P43406

RefSeq (mRNA)


NM_001144999 NM_001145000 NM_002210


NM_008402

RefSeq (protein)


NP_001138471 NP_001138472 NP_002201


NP_032428

Location (UCSC)

Chr 2: 186.59 – 186.68 Mb

Chr 2: 83.72 – 83.81 Mb

PubMed search

1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9

ENSG00000138448

ENSMUSG00000027087

NM_001144999
NM_001145000
NM_002210

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Wikipedia

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