Iñigo Lopez de Mendoza y Pimentel, 4th Duke of the Infantado, (Spanish: IV Duque del Infantado, 9 December 1493 – 17 September 1566), was a Spanish nobleman. He was made a Knight of the Order of the Golden Fleece in 1546, number 193 to receive that distinction.Duke of the Infantado is a title first granted in 1475, and was inherited upon his father's death in 1531. He was also 5th Count of Saldaña, 4th Marquess of Argüeso, 4th Marquess of Campóo, 5th Marquess of Santillana, 5th Count of Real de Manzanares, Señor de Mendoza, Señor de Hita, and Señor de Buitrago.
He was the eldest son of Diego Hurtado de Mendoza y de Luna, 3rd Duke of the Infantado (1461–1531) and María Pimentel a daughter of the 4th Count and 1st Duke of Benavente, Rodrigo Alonso Pimentel and María Pacheco Portacarerro, hence also known as María Pimentel y Pacheco. His father the 3rd Duke was, like himself, a Knight of the Order of the Golden Fleece, knighted in 1519, number 156 of that order.
He had a brother known as Rodrigo de Mendoza, 1st Marquess of Montesclaros (or Montes-Claros) and a sister described as Ana de Mendoza, who married Luis de La Cerda, 1st Marquess of Cogolludo. At least one online source lists two additional sisters: María de Mendoza and Elvira de Mendoza. Juan Miguel Soler Salcedo in Nobleza Española. Grandeza Inmemorial 1520 lists all of these. He also says that he had an older brother Diego Hurtado de Mendoza y Pimentel, who died no later than 1531, and lists numerous additional younger siblings: Martín Hurtado de Mendoza y Pimentel, a second Rodrigo (Rodrigo Hurtado de Mendoza y Pimentel), Francisco Hurtado de Mendoza y Pimentel, Brianda Hurtado de Mendoza y Pimentel, Francisca Hurtado de Mendoza y Pimentel, Marina Hurtado de Mendoza y Pimentel, and another Brianda.
The duke of the Infantado had only a limited influence at the Spanish Court, because of his initial sympathy for the Revolt of the Comuneros, when he had to be imprisoned by his own father. At his court in Guadalajara, there circulated also Lutheranist and Erasmist ideas, short of heresy at that time.