This article describes the main round of the 2015–16 Women's EHF Champions League.
In each group, teams played against each other in a double round-robin format, with home and away matches against teams they did not met before. Points obtained in the group stage were taken over. After completion of the group stage matches, the top four teams of each group advanced to the quarterfinals.
In the group stage, teams are ranked according to points (2 points for a win, 1 point for a draw, 0 points for a loss). After completion of the group stage, if two or more teams have scored the same number of points, the ranking will be determined as follows (article 4.3.1, section II of regulations):
During the group stage, only criteria 1, 4 and 5 apply to determine the provisional ranking of teams.
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