Zinc-activated ion channel

ZACN
Identifiers
Aliases	ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDs	HomoloGene: 52296 GeneCards: ZACN
Gene ontology Molecular function • extracellular ligand-gated ion channel activity • zinc ion binding • ligand-gated ion channel activity • ion channel activity • serotonin-gated cation-selective channel activity Cellular component • integral component of membrane • plasma membrane • membrane Biological process • ion transmembrane transport • response to zinc ion • ion transport • signal transduction • cation transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353174	n/a
Ensembl	ENSG00000186919	n/a
UniProt	Q401N2	n/a
RefSeq (mRNA)	NM_180990	n/a
RefSeq (protein)	NP_851321	n/a
Location (UCSC)	Chr 17: 76.07 – 76.08 Mb	n/a
PubMed search		n/a

353174

n/a

ENSG00000186919

n/a

Q401N2

n/a

NM_180990

n/a

NP_851321

n/a

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach. The endogenous ligand for ZAC is thought to be Zn²⁺, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.

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