ZAP-70

ZAP70

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4XZ0, 1FBV, 1M61, 1U59, 2CBL, 2OQ1, 2OZO, 2Y1N, 3ZNI, 4A4B, 4A4C, 4K2R, 4XZ1

Identifiers

Aliases

ZAP70, SRK, STCD, STD, TZK, ZAP-70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase 70

External IDs

OMIM: 176947 MGI: 99613 HomoloGene: 839 GeneCards: ZAP70

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • receptor binding • ATP binding
Cellular component	• cytoplasm • cytosol • membrane • cell-cell junction • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • T cell receptor complex • immunological synapse • membrane raft
Biological process	• positive regulation of T cell differentiation • T cell migration • positive regulation of calcium-mediated signaling • intracellular signal transduction • adaptive immune response • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • T cell aggregation • beta selection • negative thymic T cell selection • protein phosphorylation • B cell activation • T cell differentiation • immune response • positive thymic T cell selection • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • peptidyl-tyrosine phosphorylation • innate immune response • T cell receptor signaling pathway • thymic T cell selection • positive regulation of alpha-beta T cell differentiation • T cell activation • regulation of cell proliferation • positive regulation of alpha-beta T cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7535


22637

Ensembl


ENSG00000115085


ENSMUSG00000026117

UniProt


P43403


P43404

RefSeq (mRNA)


NM_001079 NM_207519


NM_009539 NM_001289612 NM_001289765 NM_001289766

RefSeq (protein)


NP_001070 NP_997402

NP_001276541.1 NP_001276694.1 NP_033565.2 NP_001276541 NP_001276694
NP_001276695 NP_033565

Location (UCSC)

Chr 2: 97.71 – 97.74 Mb

Chr 1: 36.76 – 36.78 Mb

PubMed search

4XZ0, 1FBV, 1M61, 1U59, 2CBL, 2OQ1, 2OZO, 2Y1N, 3ZNI, 4A4B, 4A4C, 4K2R, 4XZ1

NM_009539
NM_001289612
NM_001289765
NM_001289766

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