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Yangonin

Yangonin
Yangonin.svg
Yangonin02.png
Names
IUPAC name
4-Methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one
Identifiers
500-62-9 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL1098658 N
ChemSpider 4444896 N
ECHA InfoCard 100.211.821
PubChem 5281575
UNII R970U49V3C N
Properties
C15H14O4
Molar mass 258.27 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YesYN ?)
Infobox references

Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), where it behaves as an agonist.

Yangonin displays marked in vitro toxicity on human with approximately 40% reduction in viability based on an ethidium bromide assay. The predominant mode of cell death turned out to be apoptosis rather than necrosis. No significant changes were observed in glutathione levels.


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Wikipedia

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