YWHAH

YWHAH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C63, 2C74
Identifiers
Aliases	YWHAH, YWHA1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
External IDs	MGI: 109194 HomoloGene: 37767 GeneCards: YWHAH
Gene ontology Molecular function • sodium channel regulator activity • insulin-like growth factor receptor binding • ion channel binding • protein domain specific binding • protein binding • glucocorticoid receptor binding • protein heterodimerization activity • enzyme binding • actin binding Cellular component • cytoplasm • cytosol • intercalated disc • plasma membrane • extracellular exosome • cytoplasmic vesicle membrane • mitochondrion Biological process • regulation of neuron differentiation • glucocorticoid catabolic process • membrane depolarization during action potential • substantia nigra development • regulation of sodium ion transport • regulation of synaptic plasticity • positive regulation of transcription, DNA-templated • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • negative regulation of dendrite morphogenesis • regulation of sodium ion transmembrane transporter activity • membrane organization • intracellular protein transport • glucocorticoid receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7533	22629
Ensembl	ENSG00000128245	ENSMUSG00000018965
UniProt	Q04917	P68510
RefSeq (mRNA)	NM_003405	NM_011738
RefSeq (protein)	NP_003396	NP_035868.1 NP_035868
Location (UCSC)	Chr 22: 31.94 – 31.96 Mb	Chr 5: 33.02 – 33.03 Mb
PubMed search

2C63, 2C74

7533

22629

ENSG00000128245

ENSMUSG00000018965

Q04917

P68510

NM_003405

NM_011738

NP_003396

NP_035868.1
NP_035868

14-3-3 protein eta is a protein that in humans is encoded by the YWHAH gene.

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.

YWHAH has been shown to interact with:

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Wikipedia