Y14 (gene)

RBM8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	RBM8A, BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1, RNA binding motif protein 8A
External IDs	MGI: 1913129 HomoloGene: 3744 GeneCards: RBM8A
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.1 Start 145,917,714 bp End 145,927,678 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 96,629,933 bp End 96,633,791 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • nucleic acid binding • RNA binding • mRNA binding Cellular component • cytosol • catalytic step 2 spliceosome • exon-exon junction complex • neuronal cell body • dendrite • spliceosomal complex • nucleus • cytoplasm • nucleoplasm • nuclear speck Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • RNA processing • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • mRNA export from nucleus • mRNA 3'-end processing • regulation of translation • RNA export from nucleus • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • RNA splicing • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9939	60365
Ensembl	ENSG00000265241	ENSMUSG00000038374
UniProt	Q9Y5S9	Q9CWZ3
RefSeq (mRNA)	NM_005105	NM_001102407 NM_025875
RefSeq (protein)	NP_005096	NP_001095877 NP_080151
Location (UCSC)	Chr 1: 145.92 – 145.93 Mb	Chr 1: 96.63 – 96.63 Mb
PubMed search

1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7

9939

60365

ENSG00000265241

ENSMUSG00000038374

Q9Y5S9

Q9CWZ3

NM_005105

NM_001102407
NM_025875

NP_005096

NP_001095877
NP_080151

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene.

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.

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Wikipedia