Xanthine dehydrogenase

XDH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CKJ, 2E1Q
Identifiers
Aliases	XDH, XO, XOR, xanthine dehydrogenase
External IDs	OMIM: 607633 MGI: 98973 HomoloGene: 324 GeneCards: XDH
Genetically Related Diseases
obesity
Targeted by Drug
allopurinol
Gene ontology Molecular function • iron ion binding • protein homodimerization activity • xanthine oxidase activity • flavin adenine dinucleotide binding • oxidoreductase activity, acting on CH-OH group of donors • iron-sulfur cluster binding • metal ion binding • catalytic activity • molybdopterin cofactor binding • electron carrier activity • xanthine dehydrogenase activity • oxidoreductase activity • 2 iron, 2 sulfur cluster binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors Cellular component • cytoplasm • cytosol • peroxisome • sarcoplasmic reticulum • extracellular region • extracellular space Biological process • positive regulation of p38MAPK cascade • negative regulation of protein phosphorylation • negative regulation of protein kinase B signaling • purine nucleotide catabolic process • negative regulation of endothelial cell differentiation • negative regulation of gene expression • negative regulation of endothelial cell proliferation • positive regulation of reactive oxygen species metabolic process • negative regulation of vasculogenesis • negative regulation of vascular endothelial growth factor signaling pathway • lactation • regulation of epithelial cell differentiation • xanthine catabolic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7498	22436
Ensembl	ENSG00000158125	ENSMUSG00000024066
UniProt	P47989	Q00519
RefSeq (mRNA)	NM_000379	NM_011723
RefSeq (protein)	NP_000370	NP_035853.2 NP_035853
Location (UCSC)	Chr 2: 31.33 – 31.41 Mb	Chr 17: 73.88 – 73.95 Mb
PubMed search

xanthine dehydrogenase
Identifiers
EC number	1.17.1.4
CAS number	9054-84-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

2CKJ, 2E1Q

7498

22436

ENSG00000158125

ENSMUSG00000024066

P47989

Q00519

NM_000379

NM_011723

NP_000370

NP_035853.2
NP_035853

Xanthine dehydrogenase, also known as XDH, is a protein that, in humans, is encoded by the XDH gene.

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.

Xanthine dehydrogenase catalyzes the following chemical reaction:

...
Wikipedia