XPNPEP1

XPNPEP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CTZ
Identifiers
Aliases	XPNPEP1, APP1, SAMP, XPNPEP, XPNPEPL, XPNPEPL1, X-prolyl aminopeptidase (aminopeptidase P) 1, soluble, X-prolyl aminopeptidase 1
External IDs	MGI: 2180003 HomoloGene: 6424 GeneCards: XPNPEP1
Gene ontology Molecular function • peptidase activity • aminopeptidase activity • hydrolase activity • metallopeptidase activity • protein homodimerization activity • manganese ion binding • metal ion binding • metalloaminopeptidase activity Cellular component • extracellular exosome • cytoplasm • cytosol Biological process • bradykinin catabolic process • proteolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7511	170750
Ensembl	ENSG00000108039	ENSMUSG00000025027
UniProt	Q9NQW7	Q6P1B1
RefSeq (mRNA)	NM_001167604 NM_020383 NM_001324128 NM_001324131 NM_001324132 NM_001324133 NM_001324134 NM_001324135 NM_001324136	NM_133216
RefSeq (protein)	NP_001161076 NP_001311057 NP_001311060 NP_001311061 NP_001311062 NP_001311063 NP_001311064 NP_001311065 NP_065116	NP_573479
Location (UCSC)	Chr 10: 109.86 – 109.92 Mb	Chr 19: 52.94 – 53.04 Mb
PubMed search

3CTZ

7511

170750

ENSG00000108039

ENSMUSG00000025027

Q9NQW7

Q6P1B1

NM_001324133
NM_001324134
NM_001324135
NM_001324136

NM_133216

NP_001311063
NP_001311064
NP_001311065
NP_065116

NP_573479

Xaa-Pro aminopeptidase 1 is an enzyme that in humans is encoded by the XPNPEP1 gene.

X-prolyl aminopeptidase (EC 3.4.11.9) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-prolyl aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby complementing the pancreatic peptidases. Deficiency of X-prolyl aminopeptidase results in excretion of large amounts of imino-oligopeptides in urine (Blau et al., 1988).[supplied by OMIM]

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Wikipedia