XCR1

Identifiers

XCR1, CCGPR5, X-C motif chemokine receptor 1

External IDs

MGI: 1346338 HomoloGene: 21095 GeneCards: XCR1

Gene ontology
Molecular function	• G-protein coupled receptor activity • chemokine receptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• positive regulation of cytosolic calcium ion concentration • chemotaxis • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • inflammatory response • signal transduction • chemokine-mediated signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2829


23832

Ensembl


ENSG00000173578


ENSMUSG00000060509

UniProt


P46094


Q9R0M1

RefSeq (mRNA)


NM_005283 NM_001024644


NM_011798

RefSeq (protein)


NP_001019815 NP_005274


n/a

Location (UCSC)

Chr 3: 46.02 – 46.03 Mb

Chr 9: 123.85 – 123.86 Mb

PubMed search

NM_005283
NM_001024644

NM_011798

NP_001019815
NP_005274

n/a

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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