XBP1

XBP1
Identifiers
Aliases	XBP1, TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 1
External IDs	MGI: 98970 HomoloGene: 3722 GeneCards: XBP1
Gene ontology Molecular function • RNA polymerase II transcription factor activity, sequence-specific DNA binding • estrogen receptor binding • protein homodimerization activity • RNA polymerase II transcription factor binding • protease binding • protein binding • protein kinase binding • sequence-specific DNA binding • enhancer sequence-specific DNA binding • protein heterodimerization activity • chromatin DNA binding • ubiquitin protein ligase binding • DNA binding • core promoter binding • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding Cellular component • cytosol • membrane • integral component of membrane • nucleoplasm • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • cytoplasm • endoplasmic reticulum • nucleus Biological process • positive regulation of MHC class II biosynthetic process • positive regulation of protein phosphorylation • negative regulation of endoplasmic reticulum unfolded protein response • positive regulation of immunoglobulin production • muscle organ development • vascular endothelial growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • apoptotic process • regulation of transcription, DNA-templated • regulation of protein stability • glucose homeostasis • transcription, DNA-templated • cell growth • positive regulation of endothelial cell apoptotic process • response to unfolded protein • fatty acid biosynthetic process • protein transport • positive regulation of TOR signaling • exocrine pancreas development • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • cell differentiation • positive regulation of autophagy • cellular response to laminar fluid shear stress • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • positive regulation of B cell differentiation • negative regulation of transcription from RNA polymerase II promoter • cellular response to fluid shear stress • organelle organization • positive regulation of transcription factor import into nucleus • regulation of autophagy • immune response • transport • positive regulation of proteasomal protein catabolic process • positive regulation of plasma cell differentiation • positive regulation of T cell differentiation • positive regulation of endoplasmic reticulum unfolded protein response • positive regulation of histone methylation • lipid metabolic process • epithelial cell maturation involved in salivary gland development • positive regulation of protein acetylation • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • autophagy • multicellular organism development • ATF6-mediated unfolded protein response • IRE1-mediated unfolded protein response • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • epithelial cell maturation • cellular response to oxidative stress • cellular response to vascular endothelial growth factor stimulus • positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter • protein destabilization • cellular response to peptide hormone stimulus • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pathway-restricted SMAD protein phosphorylation • adipose tissue development • positive regulation of vascular associated smooth muscle cell migration • liver development • cellular triglyceride homeostasis • cholesterol homeostasis • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of lactation • cellular response to amino acid stimulus • angiogenesis • cellular response to glucose starvation • response to insulin-like growth factor stimulus • negative regulation of ERK1 and ERK2 cascade • fatty acid homeostasis • positive regulation of vascular smooth muscle cell proliferation • positive regulation of hepatocyte proliferation • sterol homeostasis • cellular response to interleukin-4 • positive regulation of protein kinase B signaling • ubiquitin-dependent protein catabolic process • positive regulation of fat cell differentiation • negative regulation of apoptotic process • endothelial cell proliferation • transcription from RNA polymerase II promoter • positive regulation of cell proliferation • negative regulation of myotube differentiation • positive regulation of cell migration • endoplasmic reticulum unfolded protein response • cellular response to nutrient • cellular response to insulin stimulus • response to endoplasmic reticulum stress • positive regulation of vascular wound healing • positive regulation of angiogenesis • neuron development • positive regulation of immunoglobulin secretion • cellular response to lipopolysaccharide • cellular response to fructose stimulus • cellular response to glucose stimulus • positive regulation of interleukin-6 secretion • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7494	22433
Ensembl	ENSG00000100219	ENSMUSG00000020484
UniProt	P17861	O35426
RefSeq (mRNA)	NM_005080 NM_001079539	NM_001271730 NM_013842
RefSeq (protein)	NP_001073007 NP_005071	NP_001258659.1 NP_038870.2 NP_001258659 NP_038870
Location (UCSC)	Chr 22: 28.79 – 28.8 Mb	Chr 11: 5.52 – 5.53 Mb
PubMed search

7494

22433

ENSG00000100219

ENSMUSG00000020484

P17861

O35426

NM_005080
NM_001079539

NM_001271730
NM_013842

NP_001073007
NP_005071

NP_001258659.1
NP_038870.2
NP_001258659
NP_038870

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response.

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