Sir Wylie McKissock, OBE (27 October 1906 – 3 May 1994) was a British neurosurgeon. He set up the neurosurgical unit at the Atkinson Morley Hospital, was Britain's most prolific leucotomist (lobotomist), and president of the Society of British Neurological Surgeons.
McKissock was born in Staines, Surrey. His parents were Alexander Cathie McKissock and Rae Wylie. His father, originally from Lanarkshire, was a manager in a linoleum factory who wrote crime fiction under the name of Alan Graham and invented a machine for cutting sheets of material. McKissock went to the City of London School and studied medicine at King's College London and St George's Hospital Medical School in London, qualifying in 1930. His first positions were at St George's Hospital, Maida Vale Hospital for Nervous Diseases (where he began his neurosurgical career) and Great Ormond Street Hospital. In 1936 McKissock visited to study Swedish neurosurgeon Herbert Olivecrona's work, and then spent a year (1937-1938) on a Rockefeller Foundation Fellowship in the United States and Canada. By this time he had a young family, having married Rachael Jones in 1934. The couple had two daughters and a son.
In 1939, at the outbreak of World War II, McKissock tried unsuccessfully to join the army as a neurosurgeon and instead was appointed to the neurosurgical unit at Leavesden Hospital. The unit later moved to the Atkinson Morley Hospital, Wimbledon, London, and for a time in 1944 was evacuated to Bath, Somerset. McKissock was appointed an OBE in 1946 for his neurosurgical work on casualties with brain injuries during the war. He became a consultant at St George's Hospital and was also given an appointment at the National Hospital for Neurology and Neurosurgery in Queen Square, London, the neurology unit of University College Hospital. Thus at the Atkinson Morley Hospital, which he was to run until his retirement in 1971, he operated on patients from St George's Hospital, Maida Vale Hospital, Great Ormond Street, Queen Square and University College Hospital, as well as accepting referrals from other hospitals.